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Monitor Closely (one)pentobarbital will lessen the extent or impact of cannabidiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the level or result of atogepant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Advisable atogepant dosage with concomitant utilizat